Keynote Lecture

Keynote Lecture

Үүсгэсэн огноо: 2014-09-17

When: September 19, 2014, Friday 4:00 PM

Where: Conference Hall #220, at Mongolian National University of Medical Sciences

Keynote speaker: Professor Yousuke Takahama, MD, PhD

Division of Experimental Immunology, Institute for Genome Research, Tokushima

Topic: T cell repertoire formation in the thymus



Department of Microbiology and Immunology, School of Pharmacy and Bio-

Mongolian Society of Immunology and Microbiology



Aire-expressing thymic medullary epithelial cells originate from b5t-expressing progenitor cells.

Proc Natl Acad Sci. 11;110(24):9885-90

Roberts N, et al. Rank signaling links the development of invariant γδ T cell progenitors and Aire+

Immunity. 36:427-437 (2012)

Lei Y, et al. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic

cells and contributes to regulatory T cell development.

J Exp Med. 208:383-394 (2011)

Nitta T, et al. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.

Hikosaka Y, et al. The cytokine RANKL produced by positively selected thymocytes fosters medullary

thymic epithelial cells that express autoimmune regulator.

Immunity. 29:438-450 (2008)

Murata S, et al. Regulation of CD8+ T cell development by thymus-specific proteasomes.

Science. 316:1349-1353 (2007)

Takahama Y. Journey through the thymus: stromal guides for T-cell development and selection.

Nature Rev Immunol. 6:127-135 (2006)

Kurobe H, et al. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is

essential for establishing central tolerance.

Immunity. 24:165-177 (2006)

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